Immunoinflammatory Response in Post Cardiac Arrest Syndrome (PCAS)

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This is a prospective, observational study to investigate molecular mechanisms mediating the systemic inflammatory process, and changes to metabolism, and their impact on brain injury, survival, and functional outcomes after cardiac arrest. Investigators have shown that cardiac arrest induces changes in the numbers and properties of circulating immune cells, shifting the balance towards a pro-inflammatory phenotype and there is increased interest in the inflammatory pathways and the signaling mechanisms through which they are modulated. Participants will undergo blood sampling during 7 days following cardiac arrest, and analyses performed. Patient characteristics, clinical circumstances, and outcomes will be recorded and their associations with these inflammatory pathways characterized.

Conditions:

Cardiac Arrest Inflammation Obesity

Study Start (Actual) 2016-01

Primary Completion (Estimated) 2026-01-20

Study Completion (Estimated) 2026-03-20

Enrollment (Estimated) 240

Study Type OBSERVATIONAL

Phase N/A

Locations:

📍 Portland, Maine, United States

Eligibility Criteria

Description

Inclusion Criteria:

* Aged 18 years or older
* Admitted to the intensive care unit after cardiac arrest episode
* Unresponsive after resuscitation

Exclusion Criteria:

* Moribund / actively dying at the time of evaluation
* Informed consent cannot be obtained within 24 hours of resuscitation
* Hemoglobin less than 7.0 g/dL, active high-volume bleeding, or requiring a transfusion

Ages Eligible for Study: 18 Years to N/A (ADULT, OLDER_ADULT)

Sexes Eligible for Study: ALL

Accepts Healthy Volunteers: Yes

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

First Submitted2016-01-22
First Submitted that Met QC Criteria2016-01-26
First Posted2016-01-27

Study Record Updates

Last Update Submitted that Met QC Criteria2024-03-05
Last Update Posted2024-03-07
Last Verified2024-03