The MATCH Investigation: CT Myocardial Perfusion and CT-FFR vs PET MPI

RECRUITING

I'm interested ...!!

The overall goal of this project is to compare the absolute quantification of myocardial perfusion done by using CT myocardial perfusion imaging (CT-MPI) and the coronary flow measured by using CT Fractional Flow Reserve analysis (CT-FFR) to the gold standard represented by PET myocardial perfusion imaging (PET-MPI).

Conditions:

Coronary Artery Disease

Study Start (Actual) 2021-06-16

Primary Completion (Estimated) 2024-12-31

Study Completion (Estimated) 2024-12-31

Enrollment (Estimated) 20

Study Type INTERVENTIONAL

Phase NA

Locations:

📍 Atlanta, Georgia, United States

Eligibility Criteria

Description

Inclusion Criteria:

* Referred for a clinically indicated CT-MPI for CAD assessment
* Must provide written informed consent prior to any study-related procedures being performed
* Must be willing to comply with all clinical study procedures

Exclusion Criteria:

* Pregnant or nursing females. The possibility of pregnancy will be excluded by testing (serum or urine ßHCG) within 24 hours before study agent administration, or if the woman has previous surgical sterilization, or if the woman is post menopausal, with minimum one (1) year history without menses.
* Currently taking or has taken within 48 hours the following excluded medications:
* ActoPlus Met (Pioglitazone + metformin)
* Avandamet (Rosiglitazone + metformin)
* Fortamet (metformin)
* Glucovance (Glyburide +metformin)
* Glucophage (metformin)
* Glucophage extended-release (XR) (metformin)
* Glumetza (metformin)
* Janumet (Sitagliptin + metformin)
* Metformin
* Metaglip (Glipizide + metformin)
* Riomet (metformin)
* Implanted rhythm devices (pacemaker, defibrillator)
* Acute psychiatric disorder
* Unwilling to comply with the requirements of the protocol
* Previously entered this study
* Known hypersensitivity to iodinated contrast material, beta-blockers, or pharmaceutical stressors used in this study
* Suffers from claustrophobia
* Impaired renal function (GFR \< 45 ml/min)
* Acute hypotension (\<100 mm Hg systolic)
* 2nd or 3rd degree atrioventricular (AV) block

Ages Eligible for Study: 18 Years to 85 Years (ADULT, OLDER_ADULT)

Sexes Eligible for Study: ALL

Accepts Healthy Volunteers: No

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

First Submitted2020-03-16
First Submitted that Met QC Criteria2020-03-19
First Posted2020-03-20

Study Record Updates

Last Update Submitted that Met QC Criteria2024-04-11
Last Update Posted2024-04-15
Last Verified2024-04