Inclusion Criteria:

• * Diagnosis of PCD
• 1. Clinical features consistent with PCD PLUS
• 2. At least 1 diagnostic test consistent with PCD:
• i) Biallelic pathogenic variants in PCD-associated genes identified by genetic panel testing including deletion/duplication analysis; ii) Ciliary ultrastructural defect by transmission electron microscopy known to be disease-causing, including outer dynein arm defects, outer dynein arm plus inner dynein arm (IDA) defects, IDA defects with microtubular disorganization and absent central pair
• * Age ≥ 6 years
• * At least one course of antibiotics (oral or IV) in the prior year prescribed to treat new or increased respiratory symptoms
• * Smart phone and/or internet access available in home
• * Informed consent provided by participant or parent/guardian, with assent provided as applicable

Exclusion Criteria:

• * Acute course of antibiotics for respiratory symptoms completed \<14 days prior to enrollment or Visit 1 (evaluated at enrollment and Visit 1; visit may be rescheduled \>14 days after completion of antibiotics)
• * Developmental or cognitive disability that would impair ability to complete PRO instruments or perform spirometry
• * Congenital heart disease OTHER THAN repaired or resolved atrial septal defect (ASD) or ventricular septal defect (VSD)
• * Asplenia or functional asplenia
• * Co-existing non-pulmonary disease that, in the opinion of the investigator, could have significant impact on lung function or health-related quality of life (e.g., severe scoliosis) or overall health status (e.g., cancer, severe renal disease)
• * Listed for or post-lung transplantation